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A Cure for Darkness
A Cure for Darkness
Apr 22, 2025 5:37 AM

Author:Alex Riley,Alex Riley

A Cure for Darkness

Brought to you by Penguin.

What is depression? Is it a persistent low mood or a complex range of symptoms? Is it a single diagnosis or a range of mental disorders requiring different treatments? And is there a way of curing such a complex, and diverse, condition?

A sufferer of depression himself, science writer Alex Riley has spent years thinking about these issues as he was prescribed antidepressants and underwent cognitive behavioural therapy. Throughout his treatment, he wondered-are antidepressants effective? Do short-term talking therapies actually work? And what is on the horizon for those who don't respond to these first-line treatments? A Cure for Darkness explores all of these questions and more, as the author embarks on a journey to illuminate one of the world's most prevalent disorders.

Weaving personal and family history, the book tracks treatments through centuries of science, from the 'talking cure' to electroconvulsive therapy to magic mushrooms. Reporting on the field of global mental health from its colonial past to the present day, Riley discovers new and exciting therapies, including how a group of grandmothers stands on the frontline of a mental health revolution. A gripping narrative journey, A Cure for Darkness delves deep into the science of mental health and finds hope at the new frontiers of treatment.

'Boldly ambitious, deeply affecting, and magisterial in scope' Steve Silberman, author of Neurotribes

© Alex Riley 2021 (P) Penguin Audio 2021

Reviews

A Cure for Darkness is both a compelling intellectual contribution and an act of generosity. Alex Riley combines meticulous reporting and evocative storytelling to reveal scientists' evolving understanding of depression and the many ways it can be treated. In this candid, accessible, era-spanning book, Riley brings rare sensitivity and lucidity to a topic that has defied comprehension for centuries, weaving a story that is both sweeping in scope and intensely personal.

—— Siri Carpenter, science journalist and editor of The Craft of Science Writing

This is a wonderful book.

—— James Rucker, lead of the Psychedelic Trials Group at King's College London

An engaging and informative book... Riley covers the field both historically and cross-culturally, while keeping the narrative flowing, rooted in his own experiences

—— Chris Dowrick, professor of primary medical care at the University of Liverpool

An outstanding achievement

—— Michael Berk, head of the IMPACT Strategic Research Centre at Deakin University, Geelong.

A delight. MacKinnon shows us afresh the world we thought we knew through a kaleidoscopic lens of startling facts, illuminating insight and flatout-wonderful writing. (Praise for The Once and Future World)

—— John Vaillant, author of The Tiger

In a large pool of often simplistic manuals for simple living, this book stands out for its curiosity, humanity and genuinely global appreciation of why we consume too much and what to do about it

—— Frank Trentmann, author of Empire of Things

Dissecting the dilemma at civilization's heart - the burden that reckless growth heaps upon the faltering Earth - J.B. MacKinnon lays out a wealth of knowledge and wisdom in a gripping, page-turning read. With wit, precision, and startling insights from around the world, he looks deeply into what we have done, and might do so much better. A model of clarity and grace, The Day the World Stops Shopping is one of the most important and well-written books I have read

—— Ronald Wright, author of A Short History of Progress

A welcome and rare mix: a strong environmental argument and a jaunty picaresque. For the former, MacKinnon makes a convincing case that we need to shop less now. Green consumerism, in MacKinnon's telling, isn't just about buying ecologically-sound stuff or recycling our rubbish. It's about buying many fewer things, leaving us so much less to recycle in the first place. You will want to buy this book and after you read it, little else

—— Alissa Quart, author of Squeezed: Why Our Families Can’t Afford America and Branded: The Buying and Selling of Teenagers

A provocative thought experiment that asks us to imagine what currently seems unthinkable, this is a beautifully written and rigorously researched revelation, an extraordinary creative journey to a place we urgently need to go. Full of hope and deep thought, unassuming and devoid of preaching, it is an exciting and truly inspiring read. I couldn't put it down

—— Joel Bakan, author of The Corporation: The Pathological Pursuit of Profit and Power and The New Corporation: How “Good” Corporations are Bad for Democracy

A delight. MacKinnon has given us a powerful exploration of a riddle central to our days and lives: how we are what we buy, and how buying less might make us so much more

—— Andrew Blum, author of Tubes and The Weather Machine

One of those rare reading experiences that can change the way you see everything around you, recommended for anyone interested in anything that lives and breathes (Praise for The Once and Future World)

—— The Globe and Mail

A beautifully written meditation on natural history and memory, full of new revelations. (Praise for The Once and Future World)

—— New York Times

Deep and lovely thinking and writing. (Praise for The Once and Future World)

—— Bill McKibben

MacKinnon is one of the most important ecological writers of our time. (Praise for The Once and Future World)

—— Quill & Quire

'Unique and utterly riveting, Projections braids together three skeins from Karl Deisseroth's life: his painstaking clinical experience as a psychiatrist, dedicated to helping patients; his ingenious inventions in biotechnology that have ushered in waves of new insights into how brains work; and his life as a humble and caring social human being with a gift for crafting a spellbinding chronicle. This is a masterpiece written for each and every one of us'

—— Patricia Churchland, author of Conscience

'Karl Deisseroth is already known around the world as a groundbreaking scientist who has pioneered dazzling new techniques for investigating the brain. In this enthralling masterpiece of a book, he demonstrates that he is also a perceptive psychiatrist, as well as a spellbinding writer who beautifully connects the inner feelings within all human beings to deep insights from modern psychiatry and neuroscience'

—— Robert Lefkowitz, Nobel Laureate and author of A Funny Thing Happened on the Way to Stockholm

'We are living during a revolution in our understanding of the human brain, and Karl Deisseroth has been at the forefront of these advances. This magisterial work shows that not only is he one of our leading scientists, but also a gifted writer and storyteller. With precise yet luminous prose, he merges stories of cutting-edge neuroscience with a deep reverence for his patients' humanity'

—— Neil Shubin, author of Some Assembly Required

'Deisseroth writes of heartbreaking and desperate medical cases with a doctor's knowledge, and a novelist's skill for narrative. I could not put this book down'

—— May-Britt Moser, Nobel Laureate

Gorgeous...A personal reckoning that cuts right to the heart. This beautiful novel is an ode-if not an elegy-to an endangered planet and the people and places we love

—— Literary Hub

A good nautical adventure...The Last Migration moves at a fast, exciting clip, motored as much by love for 'creatures that aren't human' as by outrage at their destruction

—— The Wall Street Journal

An ode to our disappearing natural world

—— Newsweek

You can practically hear the glaciers cracking to pieces and the shrill yelps of the circling terns

—— Vulture

There's a brooding lushness to this novel's prose that belies its stark premise... this keening lament of an adventure is compelling.

—— Hephzibah Anderson , Observer

A fascinating hybrid of nature writing and dystopian fiction... gripping... by merging cli-fi and nature writing, the novel powerfully demonstrates the spiritual and emotional costs of environmental destruction

—— The Economist

I’m a sucker for a complicated narrator, and Franny Stone might be the queen of them all. In this tantalizingly beautiful epic, Franny’s life has been marked by secrets and loss, and so she turns to where she cannot reach: the skies

—— Lauren Puckett , Elle US

Gripping, tender and beautifully done. This novel is as intimate as it is urgent—you emerge thrilled and dazed, but also galvanized to save the planet

—— Anna Funder, author of Stasiland

Visceral and haunting...This novel's prose soars with its transporting descriptions of the planet's landscapes and their dwindling inhabitants, and contains many wonderful meditations on our responsibilities to our earthly housemates...The Last Migration is a nervy and well-crafted novel, one that lingers long after its voyage is over

—— The New York Times Book Review

Dreamy, elegiac... both an adventure story and a piece of speculative climate fiction, constantly slipping between a kind of literary realism and more magical elements, between moments of domestic drama and sweeping epic... an aching and poignant book, and one that's pressing in its timeliness... It's also a book about love, about trying to understand and accept the creatureliness that exists within our selves, and what it means to be a human animal, that we might better accommodate our own wildness within the world.

—— Fiona Wright , Guardian Australia

Gutting and gorgeous, The Last Migration is an astounding meditation on love, trauma, and the cost of survival. With soulful prose and deep empathy, Charlotte McConaghy weaves parallel stories of a woman and a world on the brink of devastation, but never without hope. Equal parts love letter and dirge, this is a true force of a book that I read holding my breath from its start to its symphonic finish

—— Julia Fine, author of What Should Be Wild

At a time when it feels like we're at the end of the world, this novel about a different kind of end of the world serves as both catharsis and escape

—— Harper's Bazaar US

This novel is enchanting, but not in some safe, fairy-tale sense. Charlotte McConaghy has harnessed the rough magic that sears our souls. I recommend The Last Migration with my whole heart

—— Geraldine Brooks, Author of March

Powerful...Vibrant...Unique... If worry is the staple emotion that most climate fiction evokes in its readers, The Last Migration - the novelistic equivalent of an energizing cold plunge - flutters off into more expansive territory

—— Los Angeles Times

How far do we have to go to escape our pasts and find ourselves? Charlotte McConaghy’s luminous, brilliant novel, set in a future when wildlife is rapidly becoming extinct, is indeed about loss—but what makes it miraculous is that it is also about both the glimpses of hope and the shattering persistence of love, if we are only brave enough to acknowledge them. Written in prose as gorgeous as the crystalline beauty of the Arctic, The Last Migration is deeply moving, haunting, and, yes, important

—— Caroline Leavitt, author of Pictures of You

A lovely, haunting novel about a troubled woman’s quest to follow the last surviving Arctic terns on their southerly migration. As she tries to make peace with the ghosts of her painful past, she must choose whether she herself wants – or deserves – to survive, in spite of everything she, and all humans, have destroyed and lost

—— Ceridwen Dovey, author of In the Garden of the Fugitives

This book is a powerful - and entertaining - corrective to the idea that the only hopes that matter on this planet are those of our own species.

—— Tim Adams , Guardian

Macdonald has a wonderful gift for exploring the intersection between nature and our experience of it, in writing that is both lyrical and impassioned.

—— Hannah Beckerman , Observer

One of the most beautiful memoirs I've ever read. This story will say with you long after you put the book down

—— Emma Gannon

I just turned the last page (reluctantly!). A bold, often brutal exploration of memory, grief and love. Full of hope and heart. I can't recommend it enough

—— Terri White, author of Coming Undone

A brave, brilliant book that is both beautiful and important. Read it then buy it for all your friends

—— Hello!

Gavanndra's memoir The Consequences of Love is absolutely beautiful. It's compelling, heartbreaking, sweet, honest, fascination. I recommend it HIGHLY. I absolutely LOVED it.

—— Marian Keyes

This stunning exploration of grief is so well written and profoundly moving

—— Good Housekeeping

An elegant study of grief and memory

—— Guardian

Hodge pours heartbreak and love into the pages of a book that never pretends to know the answers, and is all the better for it

—— Sunday Times

An eye-opening snapshot of the fashion world in '90s London

—— Vogue UK
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