'I find myself at a loss for how to describe this remarkable work. Just as Karl has, through his laboratory, reimagined, and literally redefined how we view the human brain, he has reimagined and redefined what literary non-fiction can be, with great elegance. For all of us who write about science for the public, this will be a tough act to follow. It's poetic, mind-stretching, and through it all, deeply human'

'Revelatory ... it recalls the case histories of Oliver Sacks, at times the sweep of Yuval Harari's Sapiens. He writes with an evident love of words - but also, with a lucid line of scientific enquiry'

'There are some books that you read and forget. There are others that you read and think about occasionally. Then there are rare gems like Connections that you read, read again and find that the way you think has been irreversibly changed. Incredibly powerful'

'Karl Deisseroth is a master storyteller. Armed with an abundance of compassion and curiosity, he takes us on a spellbinding tour of the mysteries of the human mind through a series of fascinating case studies. His graceful prose weaves a tapestry of complex ideas into memorable stories, each illuminated by cutting-edge science. A delight from the opening paragraph to the stunning conclusion, this book is an invitation to reverence for the complexity of the human brain and its relationship to the mind: a ticket to a state of wonder at the essence of our selves'

'Deisseroth is a talented writer ... It is in his encounters with distressed patients that his talent for marrying science and the imagination becomes most apparent and that his writing comes truly alive. Connections warrants comparison with books such as Do No Harm by Henry Marsh and Brainstorm by Suzanne Sullivan . . . Deisseroth achieves the difficult feat of moving and enlightening the reader at the same time ... [this is] a book that is beautiful to read and packed with cutting edge science'

'This hybrid memoir, by an emergency-room psychiatrist and professor of psychiatry and bioengineering, probes the evolutionary origins of human emotions'

'Essential...tinged with a profound humility built over years of interactions with patients... this is big'

'Deisseroth is a genuine pioneer, whose prize-winning research is re-defining our understanding of the brain... a stunning work from a relatively young man set on revealing the threads connecting our most pressing personal concerns with our timeless biological inheritance... Deisseroth has the imagination and literary gift to make it speak to all of us'

'Karl Deisseroth's imaginative narrative flows effortlessly... There is a first love of reading and writing and hints of a literary imagination that draws on James Joyce and Toni Morrison... Deisseroth endeavors to find an emotive language for the psychiatric patients he meets. He accomplishes this by weaving together... psychiatric knowledge, technology, and imagination. These together free him to write poetically... His narratives are always sensitive... an admixture of fact and fiction, reality and imagination, damage and desire'

'[Deisseroth's] scintillating and moving analysis of the human brain and emotions, based on observations of his patients, proves he is not exaggerating. It is also a great read'

'I've known Karl as a colleague, a scientist whose discoveries in the lab have been breathtaking and revolutionary. Maybe I shouldn't be surprised to discover he's also a stunning writer, his words guiding us to a profound understanding of the nature of human emotions, seamlessly invoking Ovid and optogenetics, Borges and basal ganglia as he takes on this journey. Projections is a tour de force'

'Karl Deisseroth intertwines neuroscience and human stories in a way that is altogether new: technical, lyrical, and deeply compassionate all at once. Through sharing what he's learned as a groundbreaking scientist and a psychiatrist caring for patients with severe illness, he reveals glimmer of what makes us human. This is a crucial book for anyone who loves science, anyone who loves someone suffering from a disorder of the brain, or anyone who, like so many of us, loves both'

'The writing in this exploration of what causes human emotion at a cellular level is extraordinarily good, inviting comparisons with the work of Oliver Sacks and Henry Marsh' (Editor's Choice)

'Deisseroth, professor of psychiatry at Stanford University, melds the personal with the clinical in his masterful debut on how the human mind works and what can be learned when it goes awry ... writing with abundant empathy, Deisseroth brings his patients' struggles to life as he educates about both neuroscience and humanity. This is a must-read'

'Unique and utterly riveting, Projections braids together three skeins from Karl Deisseroth's life: his painstaking clinical experience as a psychiatrist, dedicated to helping patients; his ingenious inventions in biotechnology that have ushered in waves of new insights into how brains work; and his life as a humble and caring social human being with a gift for crafting a spellbinding chronicle. This is a masterpiece written for each and every one of us'

'Karl Deisseroth is already known around the world as a groundbreaking scientist who has pioneered dazzling new techniques for investigating the brain. In this enthralling masterpiece of a book, he demonstrates that he is also a perceptive psychiatrist, as well as a spellbinding writer who beautifully connects the inner feelings within all human beings to deep insights from modern psychiatry and neuroscience'

'We are living during a revolution in our understanding of the human brain, and Karl Deisseroth has been at the forefront of these advances. This magisterial work shows that not only is he one of our leading scientists, but also a gifted writer and storyteller. With precise yet luminous prose, he merges stories of cutting-edge neuroscience with a deep reverence for his patients' humanity'

'Deisseroth writes of heartbreaking and desperate medical cases with a doctor's knowledge, and a novelist's skill for narrative. I could not put this book down'

The book that changed my life... it's just brilliant.

Always beguiling, her writing is powerful, incisive and so singular that it defies categorization ... raw, honest and urgent... [Nelson] always prompt me to see some aspect of life very differently.

On Freedom is brave, sprawling, more troublesome than trouble-shooting - and in the spirit of Donna Haraway's Staying with the Trouble, quoted here by Nelson, that's just as it should be.

Maggie Nelson writes with a luminosity that is, upon opening any one of her books, immediately enlivening.

A patient and astringent analysis of what we owe each other and what we owe ourselves, and how to balance the two demands.

My first choice is Nomad Century by Gaia Vince, a brilliant and disturbing analysis of how climate change will affect the world's migration patterns. Vince argues that, instead of being afraid, we should embrace these new migratory movements. After all, she says, civilisations have all been built on the backs of migration. It is both a disturbing and a hopeful read

Got to be one of the most important books in the world today

A brilliantly written book, weaving together scientific, historical and environmental information with first-hand reporting, this is a powerful account of the threat to some of the world's most remarkable foods and the people who produce them

Stirring, surprising and beautifully written, Otherlands offers glimpses of times so different to our own they feel like parallel worlds. In its lyricism and the intimate attention it pays to nonhuman life, Thomas Halliday's book recalls Rachel Carson's Under the Sea Wind, and marks the arrival of an exciting new voice

Imaginative

This study of our prehistoric earth is "beyond cinematic", James McConnachie says. "It could well be the best book I read in 2022

It's phenomenally difficult for human brains to grasp deep time. Even thousands of years seem unfathomable, with all human existence before the invention of writing deemed 'prehistory', a time we know very little about. Thomas Halliday's book Otherlands helps to ease our self-centred minds into these depths. Moving backwards in time, starting with the thawing plains of the Pleistocene (2.58 million - 12,000 years ago) and ending up in the marine world of the Ediacaran (635-541 mya), he devotes one chapter to each of the intervening epochs or periods and, like a thrilling nature documentary, presents a snapshot of life at that time. It's an immersive experience, told in the present tense, of these bizarre 'otherlands', populated by creatures and greenery unlike any on Earth today

Each chapter of this literary time machine takes us further back in prehistory, telling vivid stories about ancient creatures and their alien ecologies, ending 550 million years ago

The largest-known asteroid impact on Earth is the one that killed the dinosaurs 65?million years ago, but that is a mere pit stop on Thomas Halliday's evocative journey into planetary history in Otherlands. Each chapter of this literary time machine takes us further back into the deep past, telling vivid stories about ancient creatures and their alien ecologies, until at last we arrive 550?million years ago in the desert of what is now Australia, where no plant life yet covers the land. Halliday notes the urgency of reducing carbon emissions in the present to protect our settled patterns of life, but adds: "The idea of a pristine Earth, unaffected by human biology and culture, is impossible." It's an epic lesson in the impermanence of all things

The world on which we live is "undoubtedly a human planet", Thomas Halliday writes in this extraordinary debut. But "it has not always been, and perhaps will not always be". Humanity has dominated the Earth for a tiny fraction of its history. And that History is vast. We tend to lump all dinosaurs, for example, into one period in the distant past. But more time passed between the last diplodocus and the first tyrannosaurus than has passed between the last tyrannosaurus and the present day. A mind-boggling fact. This is a glorious, mesmerising guide to the past 500 million years bought to life by this young palaeobiologist's rich and cinematic writing

A book that I really want to read but haven't yet bought - so I hope it goes into my Christmas stocking - is Otherlands: A World in the Making by Thomas Halliday. It sounds so amazing - a history of the world before history, before people. He's trying to write the history of the organisms and the plants and the creatures and everything else as the world grows from protozoic slime or whatever we emerged from. It sounds like an absolutely incredible effort of imagination. I think that Christmas presents should be books you can curl up with and get engrossed in and transported by - and Otherlands sounds like exactly that

But, of course, not all history is human history, Otherlands, by Thomas Halliday, casts its readers further and further back, past the mammoths, past the dinosaurs, back to an alien world of shifting rock and weird plants. It is a marvel