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The Compatibility Gene
The Compatibility Gene
Nov 15, 2024 12:38 PM

Author:Daniel M Davis

The Compatibility Gene

Short-listed for the Society of Biology Book Award 2014

Long-listed for the Royal Society Winton prize for science books 2014

In The Compatibility Gene, leading scientist Daniel M Davis tells the story of the crucial genes that define our relationships, our health and our individuality.

We each possess a similar set of around 25,000 human genes. Yet a tiny, distinctive cluster of these genes plays a disproportionately large part in how our bodies work. These few genes, argues Davis, hold the key to who we are as individuals and our relationship to the world: how we combat disease, how our brains are wired, how attractive we are, even how likely we are to reproduce.

The Compatibility Gene follows the remarkable history of these genes' discovery. From the British scientific pioneers who struggled to understand the mysteries of transplants to the Swiss zoologist who devised a new method of assessing potential couples' compatibility based on the smell of worn T-shirts, Davis traces a true scientific revolution in our understanding of the human body: a global adventure spanning some sixty years.

'Unusual results, astonishing implications and ethical dilemmas' The Times

'Packed with an insider's knowledge' New York Times

'He makes immunology as fascinating to popular science readers as cosmology, consciousness, and evolution' Steven Pinker

'An elegantly written, unexpectedly gripping account' Bill Bryson Guardian, Books of the Year

Daniel M Davis is director of research at the University of Manchester's Collaborative Centre for Inflammation Research and a visiting professor at Imperial College, London. He has published over 100 academic articles, including papers in Nature and Science, and Scientific American. He has won the Oxford University Press Science Writing Prize and given numerous interviews for national and international media. He was elected a Fellow of the Academy of Medical Sciences in 2011.

Reviews

Who am I? What makes me different from everyone else? Daniel Davis recounts the remarkable science that has answered one version of these questions

—— Steven Pinker

Ostensibly about a set of genes that we all have and need, this book is really about the men and women who discovered them and worked out what they do. It's a search for the essence of scientific greatness by a scientist who is headed that way himself

—— Armand Marie Leroi, author of 'Mutants'

The Compatibility Gene cuts through the complexity to reveal the startling truth about perhaps the most important section of the molecule that defines what it means to be human

—— Steve Jones, author of 'Almost Like A Whale'

Davis weaves a warm biographical thread through his tale of scientific discovery, revealing the drive and passion of those in the vanguard of research

—— The Times

Davis makes the twists and turns all count

—— Guardian

Davis ranges energetically through the research. Cultural references and anecdotes abound

—— Nature

A fascinating, expertly told story

—— Michael Brooks , New Statesman

The genes that make you a true individual ... Davis provides a well-written and easy-to-read account of the sometimes complicated biology behind the crucial genes that affect our lives so profoundly

—— New Scientist

Wonderful pen-portraits of the many scientists involved in this fast-moving field ... 5 out of 5 stars

—— Henry Gee , BBC Focus magazine

Dr. Davis's readable and informative book takes the reader into unexpectedly interesting corners of both the immune system and the lives of immunologists. It is packed with an insider's knowledge - not just of the field, but of where its bodies are buried

—— Nicholas Wade , New York Times

An elegantly written, unexpectedly gripping account of how scientists painstakingly unravelled the way in which a small group of genes ... crucially influence, and unexpectedly interconnect, various aspects of our lives... Lab work has rarely been made to seem more interesting or heroic

—— Bill Bryson , Guardian, Books of the Year 2013

What she has achieved is a very rare thing in literature - a completely realistic account of a human relationship with animal consciousness… It is a soaring performance and Mabel is the star.

—— John Carey , Sunday Times

Cunningly plaited and – almost – devastating… It deserves to sell shedloads and win prizes, it is naturalist writing of that spectacular quality that is literature too.

—— Angus Clarke , The Times

A wondrous book of loss and recovery… When [Macdonald] matches her factual know-how…with her poet’s eye, it is excellent… An exceptional book of twisted growth.

—— Tim Dee , National

Absorbing… This memoir is lit with flashes of that grace, a grace that sweeps down to the reader to hold her wrist tight with beautiful, terrible class. The discovery of the season.

—— Erica Wagner , The Economist

Astounding.

—— Bookseller

People talk about books that change your life. I loved the fact that this book does something much more valuable. It doesn’t change anything. It leaves everything just where it was, only more so; more distinct, more itself. It opens your eyes. And it deepens what we have always known; that we live side by side with each other, as we do with the creatures around us.

—— Laura Beatty , Caught by the River

A talon-sharp memoir that will thrill and chill you to the bone... Fascinating.

—— Craig Brown , Mail on Sunday

Mesmerising, decisive and devastating… Her description of Mabel in flight should be etched into every birdwatcher's field guide... Macdonald is a nature writer supreme, arguably the best practitioner of this art form writing today.

—— Stuart Winter , Sunday Express

A soaring triumph.

—— Christian House , Daily Telegraph

Beautiful.

—— Sport

Strange yet compelling... Macdonald’s poetic prose soars… An uplifting message that…sends the heart soaring.

—— Gerard Henderson , Daily Express

Vivid and fascinating.

—— James Attlee , Independent

Soars beyond genres, and burns with emotional and intellectual intensity.

—— Nature

We can’t recommend this strange, clever, beautiful book highly enough.

—— Jarrold's Bookshop , Eastern Daily Press

A soliloquy that sings from the pages. Truly beautiful.

—— Rufus the Hawk , Twitter

Heartbreaking.

—— Grazia

In fifty years time – a hundred – H is for Hawk will still defy easy definition. Readers will see wildness a little differently and they will still finish with a silent cheer for a fellow human starting to re-engage with the world. File under classic.

—— Nigel Roby , We Love This Book

Poetic, imaginative and richly persuasive prose. Macdonald’s sensitivity to English weather, landscape and natural habitat is extraordinary; she is a word-painter of the subtlest palette and an audio recorder of peerless quality.

—— Book Oxygen

Macdonald makes nature writing new.

—— For Books Sake

Extraordinary… A searing study of bereavement and a meditation on man’s place in the natural world… Written with vigour, leavened with humour, it doesn’t just sing, it flies.

—— Maggie Ferguson , Intelligent Life

Unusual and incredibly moving.

—— Twin Magazine

A masterpiece.

—— Metro , Patricia Nicol

Very rarely does a book reach out to its readers in such an immediate and engaging manner… A page-turning saga full of profound reflection… A truly remarkable achievement… This book transcends nature writing. Its quality of distinction is apparent before any exercise of critical faculty.

—— John Lister-Kaye , WOW247

Macdonald is her father’s daughter; she takes photographs, but with words, brilliant ones. H is for Helen… G is for good.

—— John Lewis-Stempel , BBC Countryfile

Strange and beautiful… An incredible achievement.

—— Kevin Jackson , Literary Review

It is in her descriptions of nature that Macdonald really excels… And…it’s the hawks themselves…which really come alive.

—— James Mcconnachie , Spectator

Never has the eye of a raptor assumed such fearful, beautiful meaning.

—— Philip Hoare , New Statesman

Big-hearted, joyful and blazing with gorgeous descriptions of nature, H is for Hawk is an unusual but very special memoir.

—— Good Housekeeping

Lyrical, headlong, humourous.

—— Iain Finlayson , New Statesman

As phenomenal, unusual, moving and agile as a fearsome bird of prey.

—— Monocle

Helen’s skill is to cover so much beneath the camouflage of ‘nature writing’ – with perceptive, far-reaching and rather beautiful results.

—— Galen O'Hanlon , Skinny

An elegant, disturbing and heart-warming book.

—— Wharfedale Observer

A brilliantly beautiful evocation which interweaves her experiences as an austringer, a grieving daughter, an academic and simply a human being.

—— Allen Sleith , Belfast Telegraph

Destined to be a nature classic.

—— Bath Magazine

It is moving and personal in a way that few books of this kind are.

—— Gabriel Smith , Cotswold Life

H is for Hawk is a mature, accomplished work: a touchstone for future memoirs, bibliomemoirs, and writing that deals with the natural environment and the self.

—— The Times Literary Supplement

Beautifully written and interposed with literary references, it will captivate book lovers and bird lovers alike.

—— Catriona Gray , House and Garden

Likely to leave a lasting impression.

—— Scotland Outdoors

This is an encounter with a bird many of us only dream of seeing in the wild, so read this and fill a void.

—— John Miles , Bird Watching

You won’t find a better nature book this year.

—— Fanny Blake , Woman and Home

This part-memoir, part-history, part-nature combination could have gone dreadfully wrong but it doesn’t. In fact, like Mabel, it flies.

—— Alan Johnson MP , Radio Times

Somehow the book had rattled me so much that, even after finishing it, I couldn’t let it go.

—— Julie Myerson , Guardian

Helen Macdonald’s book is a worthy and unusual winner; it’s part grief-memoir, part history of falconry.

—— Robbie Millen , The TImes

H is for Hawk deserves its acclaim as a classic of its kind.

—— David Sexton , Evening Standard

A great read.

—— Western Morning News

Macdonald’s unusual approach and her resonant natural descriptions make it an outstanding book.

—— Sameer Rahim , Telegraph

H is for Hawk…is the most “A for Amazing” book I've read in a long while.

—— Alan Johnson , Spectator

The deserved winner of the Samuel Johnson Prize, this is one of the most original works you’ll read this year.

—— Daily Telegraph

The passion and conviction with which Macdonald tells an extraordinary story transcends any fear that this will be another “nature story”. Instead it is fascinating, moving and gripping throughout.

—— Alex Larman , Daily Express

Winner of 2014’s Samuel Johnson prize, this is a captivating nature book as well as a moving elegy on love and life.

—— Kate Figes , Mail on Sunday

The book is almost faultless in its exploration of the relationship with one’s own consciousness as well as that of an animal.

—— Helen Davies , Sunday Times

I’ve never read anything like it before… The last lines brought tears to my eyes.

—— Ruth Rendell , Guardian

I must agree with the judges of the Samuel Johnson prize. Helen Macdonald’s incredible H Is for Hawk…is a truly original mixture… It is, as the flyleaf predicts, destined to become a classic of nature writing.

—— Stephen Moss , Guardian

H is for Hawk is an extraordinary achievement – and a salutary reminder that animals are not symbols, but co-tenants of our living landscape.

—— Melissa Harrison , The Times

Helen Macdonald’s prose streams on to the page with absolute clarity in this extraordinary book.

—— Pat Ashworth , Church Times

It really has been a privilege to read this book.

—— Dovegreyreader scribbles (blog)

Although grief is the engine of the story, its most exceptional aspect is the beauty and force of its descriptions of birds and landscape, and its real star is the goshawk.

—— Paul Laity , Guardian

The winner of this year's Samuel Johnson Prize is one of the most captivating books I've read.

—— Lucy Scholes , Independent

It is in no way a misery memoir. It is uplifting, poetic, exhilarating.

—— Jackie Kay , Scotsman

What makes the book outstanding is the beauty of her prose. It rightly won the prize.

—— Alan Johnson , Mail on Sunday

Combining nature writing of the highest order…with a deeply affecting meditation on bereavement, this looks set to become a classic.

—— Mail on Sunday

One of the most all-consumingly wonderful books I’ve read in ages.

—— Kate Kellaway , Observer

Emphatically my book of the year.

—— John Lister-Kay , Scotsman

I’ve read excerpts from this book and it sounds wild and strange and haunting.

—— Francesca Simon , UK Press Syndication

It’s worthy winner most in that it shows how diverse non-fiction can be in itself.

—— Stuart Kelly , Scotsman

It’s a treat – a truly original, if slightly mad, book.

—— Robbie Millen , The Times

I have never read anything that evokes the strange and broken landscape of bereavement more accurately.

—— Alexandra Blakemore , Times Higher Education

Ultimately uplifting about the power of life, this has to be one of the best books of the year.

—— Bob Johnstone , Newstalk

It is a timeless classic that leaves you wondering how you did without it before.

—— Paul McNamee , Big Issue

Wonderful.

—— Bel Mooney , Daily Mail

The book is unforgettable.

—— Michael McCarthy , Independent

Her book is so good that, at times, it hurt me to read it. It draws blood, in ways that seem curative.

—— Dwight Garner , New York Times

To categorize this work as merely memoir, nature writing or spiritual writing would understate [Macdonald’s] achievement

—— Karin Altenberg , Wall Street Journal (Europe)

Captivating and beautifully written, it’s a meditation on the bond between beasts and humans and the pain and beauty of being alive

—— People Magazine

To come across writing this good…is like spotting a swooping bird of prey on a woodland walk; it’s unexpected and thrilling, and the experience stays with you

—— David Evans, 5 stars , Independent

It’s completely original

—— Peter Duncan , Daily Express

Macdonald writes poignantly but avoids sentimentality on taking her reader on this journey of discovery and ultimately of liberation

—— Good Book Guide

Both sad and beautiful

—— Kate Phelan , Vogue

Macdonald’s nature writing is truly breathtaking… H is for Hawk is a work that beautifully explores the natural in the midst of the very personal

—— Ben Walter , Journeys Magazine

probably one of the most unusual non-fictions books I’ve read, but… one of the most heartfelt and intriguing ones

—— Reading Matters

poetic and intriguing

—— Louise Elliott , Living Magazine

H is for Hawk, her memoir of loss, writing, recovery and nature, drawing ingeniously on the life and work of T.H. White, covered this territory with ferocious honesty and eloquence

—— Sarah Ditum , Spectator

Combines lyrical nature writing with moving introspection.

—— Radio Times

Fiercely, grippingly brilliant.

—— James Macdonald , The Sunday Times

Exceptionally well researched and written… It’s a wonderful book, it made me cry.

—— Phil Williams, BBC Radio 5 Live

Macdonald's is a book about grief, the churlish indifference of the natural world to human emotions and the solitude of failure, but it is also about a "return from this strange hedgerow ontology to more ordinary humanity". It is heartbreaking and affirming at the same time.

—— Peter J. Smith , Times Higher Education Supplement

A lyrical, moving probe into both the process of mourning and our relationship with the natural world.

—— Martin Chilton, Olivia Petter and Ceri Radford , Independent, *Books of the Decade*

One of the decade’s most arresting nature books

—— Andrew Holgate , Sunday Times, *Books of the Decade*
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